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DTSTAMP:20240328T152314Z
UID:https://www.ipp.mpg.de/events/29750/4033069
DTSTART:20211203T093000Z
DTEND:20211203T110000Z
CLASS:PUBLIC
CREATED:20211129T155231Z
DESCRIPTION: Clearly\, the laws of physics hold and are exploited in living
organisms. Speaking as a physicist\, most biological characteristics stem
from the laws of classical physics that students learn in their first yea
r. However\, crucial characteristics in organisms are governed by quantum
physics. The latter characteristics are those in which biological processe
s involve the jumps of electrons from one state to another. The quantum be
havior of electrons covers all chemical transformations\, for example it a
rises in optical transitions induced through light absorption by biomolecu
les.The mechanism by which night-migratory songbirds sense the direction o
f the Earth's magnetic field appears to possibly rely on the quantum spin
dynamics of light-induced radical pairs in cryptochrome proteins located i
n the retina [1-4]. Cryptochrome binds internally the flavin cofactor (FAD
)\, which governs it signaling through light-induced electron transfer inv
olving a chain of four tryptophan residues\, TrpA\, TrpB\, TrpC\, TrpD. In
this presentation I will review the latest experimental findings [3] that
demonstrate that the photochemistry of cryptochrome 4 (CRY4) from the nig
ht-migratory European robin (Erithacus rubecula) is magnetically se
nsitive in vitro\, and more so than CRY4 from two non-migratory bird speci
es\, chicken (Gallus gallus) and pigeon (Columba livia). Sit
e-specific mutations of ErCRY4 reveal the roles of four successive flavin
–tryptophan radical pairs in generating magnetic field effects and in st
abilizing potential signaling states in a way that could enable sensing an
d signaling functions to be independently optimized in night-migratory bir
ds. The experimental findings will be closely linked to the state-of-the-a
rt computational investigations accomplished by my group in the recent yea
rs which help underpin the nature of the electron transfers and explain it
s unique features in the case of ErCRY4. REFERENCES[1] H. Mouritsen\, N
ature 558\, 50 (2018). [2] D.R. Kattnig\, J.K. Sowa\, I.A. Solov'yov\,
and P.J. Hore\, New J. Phys. 18 063007 (2016)[3] Xu\, J.\, Jarocha
\, L.E.\, Zollitsch\, T. et al. Nature 594\, 535–540 (2021)[4] E. Sjulst
ok and I.A. Solov’yov\, J. Phys. Chem. Lett 11\, 3866 (2020)\nVortragend
er: Prof. Ilia A. Solov’yov
LAST-MODIFIED:20211129T161101Z
LOCATION:Zoom Meeting Room 1\, Raum: Zoom Meeting
ORGANIZER:Dmitry Moseev
SUMMARY:Institutskolloquium: QUANTUM ORIGINS OF MAGNETIC SENSING
URL:https://www.ipp.mpg.de/events/29750/4033069
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